MOTS-C 20mg

MOTS-C | 20mg

Most peptides originate from nuclear DNA. MOTS-C is different. Encoded directly within the mitochondrial genome, MOTS-C is a 16 amino acid mitochondrial-derived peptide that represents an entirely new class of biological signalling molecule — one that communicates between the mitochondria and the nucleus to regulate whole-body metabolism, stress response, and the ageing process itself.

Naturally produced in response to exercise and cellular stress, MOTS-C levels decline significantly with age, contributing to the metabolic dysfunction, insulin resistance, and reduced physical capacity commonly associated with growing older. Restoring these levels through research supplementation is now one of the most compelling areas of metabolic and longevity science.

What Research Suggests MOTS-C May Support:

Metabolic Flexibility & Fat Oxidation — By activating AMPK — the body’s master metabolic switch — MOTS-C promotes glucose uptake, encourages fat oxidation, and supports the body’s ability to efficiently switch between fuel sources, making it a subject of significant interest in obesity and metabolic health research.

Insulin Sensitivity & Blood Sugar Regulation — Studies point to MOTS-C’s ability to improve skeletal muscle insulin response and enhance glucose clearance, with research demonstrating meaningful reductions in insulin resistance particularly in older subjects and those on high-fat diets.

Physical Performance & Muscle Health — Research in both animal models and human subjects has shown that MOTS-C supports skeletal muscle metabolism, preserves muscle function with age, and enhances physical capacity — with studies demonstrating improvements across young, middle-aged, and older subjects.

Cardiovascular Support — Studies suggest MOTS-C improves myocardial efficiency, supports healthy cardiac function, and promotes the cardiovascular benefits typically associated with exercise — even in the absence of physical activity.

Neuroprotection & Cognitive Health — Research indicates MOTS-C can cross the blood-brain barrier, support memory consolidation, and reduce neuroinflammation by downregulating pro-inflammatory cytokines in the brain — opening up promising new areas of neurodegenerative research.

Healthy Ageing & Longevity — By restoring mitochondrial-nuclear communication that diminishes with age, MOTS-C addresses one of the most fundamental biological drivers of ageing, with research pointing to meaningful improvements in healthspan and metabolic resilience over time.

For research purposes only. Not approved for human therapeutic use. Always consult a qualified healthcare professional.